Cryogel scaffolds for regionally constrained delivery of lysophosphatidylcholine to central nervous system slice cultures: A model of focal demyelination for multiple sclerosis research.

Eigel, Dimitri; Zoupi, Lida; Sekizar, Sowmya; Welzel, Petra B; Werner, Carsten; Williams, Anna; Newland, Ben

Eigel, Dimitri; Zoupi, Lida; Sekizar, Sowmya; Welzel, Petra B; Werner, Carsten; Williams, Anna; Newland, Ben.

Afiliação

Eigel D; Leibniz-Institut für Polymerforschung Dresden e.V., Max Bergmann Center of Biomaterials Dresden, Hohe Straße 6, D-01069 Dresden, Germany.
Zoupi L; MRC-Centre for Regenerative Medicine, University of Edinburgh, Edinburgh BioQuarter, 5 Little France Drive, EH16 4UU Edinburgh, UK.
Sekizar S; MRC-Centre for Regenerative Medicine, University of Edinburgh, Edinburgh BioQuarter, 5 Little France Drive, EH16 4UU Edinburgh, UK.
Welzel PB; Leibniz-Institut für Polymerforschung Dresden e.V., Max Bergmann Center of Biomaterials Dresden, Hohe Straße 6, D-01069 Dresden, Germany.
Werner C; Leibniz-Institut für Polymerforschung Dresden e.V., Max Bergmann Center of Biomaterials Dresden, Hohe Straße 6, D-01069 Dresden, Germany.
Williams A; MRC-Centre for Regenerative Medicine, University of Edinburgh, Edinburgh BioQuarter, 5 Little France Drive, EH16 4UU Edinburgh, UK. Electronic address: anna.williams@ed.ac.uk.
Newland B; Leibniz-Institut für Polymerforschung Dresden e.V., Max Bergmann Center of Biomaterials Dresden, Hohe Straße 6, D-01069 Dresden, Germany; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK. Electronic address: newlandb@c

Acta Biomater ; 97: 216-229, 2019 10 01.

Article em En | MEDLINE | ID: mdl-31425890

Assuntos

Encéfalo; Criogéis; Sistemas de Liberação de Medicamentos; Lisofosfatidilcolinas; Modelos Neurológicos; Esclerose Múltipla; Animais; Encéfalo/metabolismo; Encéfalo/patologia; Criogéis/química; Criogéis/farmacocinética; Criogéis/farmacologia; Lisofosfatidilcolinas/química; Lisofosfatidilcolinas/farmacocinética; Lisofosfatidilcolinas/farmacologia; Camundongos; Microdissecção; Esclerose Múltipla/tratamento farmacológico; Esclerose Múltipla/metabolismo; Esclerose Múltipla/patologia

Palavras-chave

Cryogel; Focal demyelination; Multiple sclerosis; Remyelination

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Lisofosfatidilcolinas / Sistemas de Liberação de Medicamentos / Criogéis / Modelos Neurológicos / Esclerose Múltipla Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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