Functional implications of pH-induced conformational changes in the Sphingosine kinase 1.

Gupta, Preeti; Khan, Faez Iqbal; Roy, Sonam; Anwar, Saleha; Dahiya, Rashmi; Alajmi, Mohammed F; Hussain, Afzal; Rehman, Md Tabish; Lai, Dakun; Hassan, Md Imtaiyaz

Gupta, Preeti; Khan, Faez Iqbal; Roy, Sonam; Anwar, Saleha; Dahiya, Rashmi; Alajmi, Mohammed F; Hussain, Afzal; Rehman, Md Tabish; Lai, Dakun; Hassan, Md Imtaiyaz.

Afiliação

Gupta P; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India.
Khan FI; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Roy S; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India.
Anwar S; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India.
Dahiya R; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India.
Alajmi MF; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Hussain A; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Rehman MT; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Lai D; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Hassan MI; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India. Electronic address: mihassan@jmi.ac.in.

Spectrochim Acta A Mol Biomol Spectrosc ; 225: 117453, 2020 Jan 15.

Article em En | MEDLINE | ID: mdl-31446356

Assuntos

Fosfotransferases (Aceptor do Grupo Álcool)/química; Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo; Dicroísmo Circular; Estabilidade Enzimática; Humanos; Ligação de Hidrogênio; Concentração de Íons de Hidrogênio; Simulação de Dinâmica Molecular; Fosfotransferases (Aceptor do Grupo Álcool)/genética; Análise de Componente Principal; Agregados Proteicos; Conformação Proteica; Estrutura Secundária de Proteína; Estrutura Terciária de Proteína; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Espectrometria de Fluorescência; Espectrofotometria; Esfingolipídeos/metabolismo

Palavras-chave

Kinase activity; Molecular dynamics simulation; Sphingosine kinase 1; Structural genomics; Structure-function relationships; pH-induced denaturation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfotransferases (Aceptor do Grupo Álcool) Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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