Evaluation of Solubility Characteristics of a Hybrid Complex of Components of Soy.
ACS Omega
; 4(5): 8632-8640, 2019 May 31.
Article
em En
| MEDLINE
| ID: mdl-31459952
ABSTRACT
The purpose of this study was to evaluate the solubilities and physicochemical properties of solid dispersions of daidzein (DDZ) and genistein (GST) (the major isoflavones in soybeans) in γ-cyclodextrin (γCD). Dispersions were prepared in distilled water using a three-dimensional ball mill (3DGMw). Phase solubility diagrams confirmed that DDZ/γCD and GST/γCD formed AL type inclusion complexes with a molar ratio of 11. A new peak due to inclusion complexes was observed in the results of powder X-ray diffraction (3DGMw(DDZ/γCD = 11) and 3DGMw(GST/γCD = 11)). Dissolution tests using distilled water found that solubilities of 3DGMw(DDZ/γCD = 11) and 3DGMw(GST/γCD = 11) were approximately 37- and 51-fold higher, respectively, than the solubilities of pure DDZ and GST. These observations are expected to expand the usefulness of cogrinding of DDZ or GST with γCD using a three-dimensional ball mill.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article