The PHD finger of Spp1 mediates histone modification cross-talk.

Musselman, Catherine A; Kutateladze, Tatiana G

Musselman, Catherine A; Kutateladze, Tatiana G.

Afiliação

Musselman CA; Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045, U.S.A. tatiana.kutateladze@cuanschutz.edu catherine.musselman@cuanschutz.edu.
Kutateladze TG; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, U.S.A. tatiana.kutateladze@cuanschutz.edu catherine.musselman@cuanschutz.edu.

Biochem J ; 476(16): 2351-2354, 2019 08 28.

Article em En | MEDLINE | ID: mdl-31462441

ABSTRACT

ABSTRACT

Binding of the Spp1 PHD finger to histone H3K4me3 is sensitive to adjacent post-translational modifications in the histone tail. This commentary discusses the findings of He and colleagues [Biochem. J.476, 1957-1973] which show that the PHD finger binds to H3K4me3 in a selective manner which is conserved in the Saccharomyces pombe and mammalian orthologues of Spp1.

Assuntos

Histonas; Dedos de Zinco PHD; Animais; Código das Histonas; Modelos Moleculares; Ligação Proteica; Processamento de Proteína Pós-Traducional

Palavras-chave

PHD finger; chromatin; epigenetic; histone

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Histonas / Dedos de Zinco PHD Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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