Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA.

Finol-Urdaneta, Rocio K; McArthur, Jeffrey R; Korkosh, Vyacheslav S; Huang, Sun; McMaster, Denis; Glavica, Robert; Tikhonov, Denis B; Zhorov, Boris S; French, Robert J

Finol-Urdaneta, Rocio K; McArthur, Jeffrey R; Korkosh, Vyacheslav S; Huang, Sun; McMaster, Denis; Glavica, Robert; Tikhonov, Denis B; Zhorov, Boris S; French, Robert J.

Afiliação

Finol-Urdaneta RK; Department of Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. rfinolu@uow.edu.au.
McArthur JR; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia. rfinolu@uow.edu.au.
Korkosh VS; Department of Biochemistry, Brandeis University, Waltham, MA 0254-9110, USA. rfinolu@uow.edu.au.
Huang S; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia.
McMaster D; I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg 194223, Russia.
Glavica R; Department of Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Tikhonov DB; Department of Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Zhorov BS; Department of Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
French RJ; I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg 194223, Russia.

Mar Drugs ; 17(9)2019 Aug 29.

Article em En | MEDLINE | ID: mdl-31470595

Assuntos

Bactérias/metabolismo; Conotoxinas/farmacologia; Bloqueadores dos Canais de Sódio/farmacologia; Canais de Sódio Disparados por Voltagem/metabolismo; Sequência de Aminoácidos; Animais; Caramujo Conus/química; Ligação Proteica

Palavras-chave

bacterial sodium channels, prokaryotic sodium channels (NavBacs); eukaryotic sodium channels (Nav1s); voltage- and use-dependent block; voltage-gated sodium channels; µ-conotoxin PIIIA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Conotoxinas / Bloqueadores dos Canais de Sódio / Canais de Sódio Disparados por Voltagem Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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