In vivo imaging of TGFß signalling components using positron emission tomography.
Drug Discov Today
; 24(12): 2258-2272, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-31494189
ABSTRACT
The transforming growth factor ß (TGFß) family of cytokines achieves homeostasis through a careful balance and crosstalk with complex signalling pathways. Inappropriate activation or inhibition of this pathway and mutations in its components are related to diseases such as cancer, vascular diseases, and developmental disorders. Quantitative imaging of expression levels of key regulators within this pathway using positron emission tomography (PET) can provide insights into the role of this pathway in vivo, providing information on underlying pathophysiological processes. PET imaging can also be used to study the drug targeting of this pathway and to detect diseases in which this pathway is disturbed. In this review, we provide an overview of PET tracers available to study the TGFß signalling pathway. In addition, we discuss future imaging targets for this pathway and possible leads for new PET tracers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Fator de Crescimento Transformador beta
/
Tomografia por Emissão de Pósitrons
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article