Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration.
Elife
; 82019 09 09.
Article
em En
| MEDLINE
| ID: mdl-31498774
ABSTRACT
Coordinated migration of cell collectives is important during embryonic development and relies on cells integrating multiple mechanical and chemical cues. Recently, we described that focal activation of the FGF pathway promotes the migration of the parapineal in the zebrafish epithalamus. How FGF activity is restricted to leading cells in this system is, however, unclear. Here, we address the role of Notch signaling in modulating FGF activity within the parapineal. While Notch loss-of-function results in an increased number of parapineal cells activating the FGF pathway, global activation of Notch signaling decreases it; both contexts result in defects in parapineal migration and specification. Decreasing or increasing FGF signaling in a Notch loss-of-function context respectively rescues or aggravates parapineal migration defects without affecting parapineal cells specification. We propose that Notch signaling controls the migration of the parapineal through its capacity to restrict FGF pathway activation to a few leading cells.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peixe-Zebra
/
Transdução de Sinais
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Movimento Celular
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Epitálamo
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Receptores Notch
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Fatores de Crescimento de Fibroblastos
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article