Multiple Roles of c-di-GMP Signaling in Bacterial Pathogenesis.
Annu Rev Microbiol
; 73: 387-406, 2019 09 08.
Article
em En
| MEDLINE
| ID: mdl-31500536
ABSTRACT
The intracellular signaling molecule cyclic di-GMP (c-di-GMP) regulates the lifestyle of bacteria and controls many key functions and mechanisms. In the case of bacterial pathogens, a wide variety of virulence lifestyle factors have been shown to be regulated by c-di-GMP. Evidence of the importance of this molecule for bacterial pathogenesis has become so great that new antimicrobial agents are tested for their capacity of targeting c-di-GMP signaling. This review summarizes the current knowledge on this topic and reveals its application for the development of new antivirulence intervention strategies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Proteínas de Bactérias
/
Transdução de Sinais
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GMP Cíclico
/
Fatores de Virulência
Tipo de estudo:
Etiology_studies
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article