Biopolymers augment viral vectors based gene delivery.
J Biosci
; 44(4)2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31502562
ABSTRACT
The success of viral vectors mediated gene therapy is still hampered by immunogenicity and insufficient transgene expression. Alternatively, non-viral vectors mediated gene delivery has the advantage of low immunogenicity despite showing low transgene expression. By carefully considering the advantages of each approach, hybrid vectors are currently being developed by modifying the viral vectors using non-viral biopolymers. This review provides an overview of the hybrid vectors currently being developed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
/
Técnicas de Transferência de Genes
/
Dependovirus
/
Vetores Genéticos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article