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Consequences of negative energy balance on follicular development and oocyte quality in primiparous sows†.
Costermans, N G J; Teerds, K J; Middelkoop, A; Roelen, B A J; Schoevers, E J; van Tol, H T A; Laurenssen, B; Koopmanschap, R E; Zhao, Y; Blokland, M; van Tricht, F; Zak, L; Keijer, J; Kemp, B; Soede, N M.
Afiliação
  • Costermans NGJ; Human and Animal Physiology, Wageningen University and Research, Wageningen, The Netherlands.
  • Teerds KJ; Adaptation Physiology, Wageningen University and Research, Wageningen, The Netherlands.
  • Middelkoop A; Human and Animal Physiology, Wageningen University and Research, Wageningen, The Netherlands.
  • Roelen BAJ; Adaptation Physiology, Wageningen University and Research, Wageningen, The Netherlands.
  • Schoevers EJ; Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  • van Tol HTA; Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  • Laurenssen B; Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  • Koopmanschap RE; Adaptation Physiology, Wageningen University and Research, Wageningen, The Netherlands.
  • Zhao Y; Adaptation Physiology, Wageningen University and Research, Wageningen, The Netherlands.
  • Blokland M; Human and Animal Physiology, Wageningen University and Research, Wageningen, The Netherlands.
  • van Tricht F; Wageningen Food Safety Research (WFSR), Wageningen University & Research, Akkermaalsbos 2, 6708WB Wageningen, The Netherlands.
  • Zak L; Wageningen Food Safety Research (WFSR), Wageningen University & Research, Akkermaalsbos 2, 6708WB Wageningen, The Netherlands.
  • Keijer J; TopigsNorsvin Research Center B. V., Beuningen, The Netherlands.
  • Kemp B; Human and Animal Physiology, Wageningen University and Research, Wageningen, The Netherlands.
  • Soede NM; Adaptation Physiology, Wageningen University and Research, Wageningen, The Netherlands.
Biol Reprod ; 102(2): 388-398, 2020 02 14.
Article em En | MEDLINE | ID: mdl-31504218
Metabolic demands of modern hybrid sows have increased over the years, which increases the chance that sows enter a substantial negative energy balance (NEB) during lactation. This NEB can influence the development of follicles and oocytes that will give rise to the next litter. To study effects of a lactational NEB on follicular development, we used 36 primiparous sows of which 18 were subjected to feed restriction (3.25 kg/day) and 18 were full-fed (6.5 kg/day) during the last 2 weeks of a 24.1 ± 0.3 day lactation. Feed restriction resulted in a 70% larger lactational body weight loss and 76% higher longissimus dorsi depth loss, but similar amounts of backfat loss compared to the full fed sows. These changes were accompanied by lower plasma insulin-like growth factor 1 (IGF1) and higher plasma creatinine levels in the restricted sows from the last week of lactation onward. Ovaries were collected 48 h after weaning. Restricted sows had a lower average size of the 15 largest follicles (-26%) and cumulus-oocyte complexes showed less expansion after 22 h in vitro maturation (-26%). Less zygotes of restricted sows reached the metaphase stage 24 h after in vitro fertilization and showed a higher incidence of polyspermy (+89%). This shows that feed restriction had severe consequences on oocyte developmental competence. Follicular fluid of restricted sows had lower IGF1 (-56%) and steroid levels (e.g., ß-estradiol, progestins, and androgens), which indicated that follicles of restricted sows were less competent to produce steroids and growth factors needed for oocytes to obtain full developmental competence.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oócitos / Lactação / Fenômenos Fisiológicos da Nutrição Materna / Metabolismo Energético / Folículo Ovariano Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oócitos / Lactação / Fenômenos Fisiológicos da Nutrição Materna / Metabolismo Energético / Folículo Ovariano Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article