Effect of topical administration of the microneurotrophin BNN27 in the diabetic rat retina.

Ibán-Arias, Ruth; Lisa, Silvia; Poulaki, Smaragda; Mastrodimou, Niki; Charalampopoulos, Ioannis; Gravanis, Achille; Thermos, Kyriaki

Ibán-Arias, Ruth; Lisa, Silvia; Poulaki, Smaragda; Mastrodimou, Niki; Charalampopoulos, Ioannis; Gravanis, Achille; Thermos, Kyriaki.

Afiliação

Ibán-Arias R; Department of Pharmacology, School of Medicine, University of Crete, 70013, Heraklion, Crete, Greece.
Lisa S; Department of Psychiatry, Laboratory of Molecular Biology and Genetics of Neurodegeneration, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Poulaki S; Department of Pharmacology, School of Medicine, University of Crete, 70013, Heraklion, Crete, Greece.
Mastrodimou N; Department of Cell Biology and Pathology, Instituto de Neurociencias de Castilla y León (INCyL) University of Salamanca & Institute of Biomedical Research, 37007, Salamanca, Spain.
Charalampopoulos I; Department of Pharmacology, School of Medicine, University of Crete, 70013, Heraklion, Crete, Greece.
Gravanis A; Department of Pharmacology, School of Medicine, University of Crete, 70013, Heraklion, Crete, Greece.
Thermos K; Department of Pharmacology, School of Medicine, University of Crete, 70013, Heraklion, Crete, Greece.

Graefes Arch Clin Exp Ophthalmol ; 257(11): 2429-2436, 2019 Nov.

Article em En | MEDLINE | ID: mdl-31512044

Assuntos

Desidroepiandrosterona/administração & dosagem; Diabetes Mellitus Experimental; Retinopatia Diabética/tratamento farmacológico; Retina/patologia; Administração Tópica; Animais; Western Blotting; Desidroepiandrosterona/farmacocinética; Retinopatia Diabética/diagnóstico; Retinopatia Diabética/metabolismo; Relação Dose-Resposta a Droga; Feminino; Masculino; Ratos; Ratos Sprague-Dawley; Retina/efeitos dos fármacos; Retina/metabolismo; Resultado do Tratamento

Palavras-chave

ERK1/2 kinases; Nerve growth factor; Neurodegeneration; Neuroprotection; Retinal disease; TrkA receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retina / Desidroepiandrosterona / Diabetes Mellitus Experimental / Retinopatia Diabética Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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