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Complete Pathological Response Following Radiochemotherapy for Locally Advanced Rectal Cancer: Short and Long-term Outcome.
Iskander, Othman; Courtot, Lise; Tabchouri, Nicolas; Artus, Alice; Michot, Nicolas; Muller, Olivier; Pabst-Giger, Urs; Bourlier, Pascal; Kraemer-Bucur, Aurore; Lecomte, Thierry; Guyetant, Serge; Chapet, Sophie; Calais, Gilles; Salamé, Ephrem; Ouaïssi, Mehdi.
Afiliação
  • Iskander O; Department of Digestive, Oncological, Endocrine, Hepato-Biliary, Pancreatic and Liver Transplant Surgery, Trousseau Hospital, Tours, France.
  • Courtot L; Department of Digestive, Oncological, Endocrine, Hepato-Biliary, Pancreatic and Liver Transplant Surgery, Trousseau Hospital, Tours, France.
  • Tabchouri N; Department of Digestive, Oncological, Endocrine, Hepato-Biliary, Pancreatic and Liver Transplant Surgery, Trousseau Hospital, Tours, France.
  • Artus A; Department of Digestive, Oncological, Endocrine, Hepato-Biliary, Pancreatic and Liver Transplant Surgery, Trousseau Hospital, Tours, France.
  • Michot N; Department of Digestive, Oncological, Endocrine, Hepato-Biliary, Pancreatic and Liver Transplant Surgery, Trousseau Hospital, Tours, France.
  • Muller O; Department of Digestive, Oncological, Endocrine, Hepato-Biliary, Pancreatic and Liver Transplant Surgery, Trousseau Hospital, Tours, France.
  • Pabst-Giger U; Department of General-, Visceral- and Transplant Surgery, University of Münster, Münster, Germany.
  • Bourlier P; Department of Digestive, Oncological, Endocrine, Hepato-Biliary, Pancreatic and Liver Transplant Surgery, Trousseau Hospital, Tours, France.
  • Kraemer-Bucur A; Department of Digestive, Oncological, Endocrine, Hepato-Biliary, Pancreatic and Liver Transplant Surgery, Trousseau Hospital, Tours, France.
  • Lecomte T; Department of Hepatogastroenterology and Digestive Oncology, Trousseau Hospital, Tours, France.
  • Guyetant S; Department of Histopathology, Trousseau Hospital, Tours, France.
  • Chapet S; Department of Radiotherapy, Bretonneau Hospital, Tours, France.
  • Calais G; Department of Radiotherapy, Bretonneau Hospital, Tours, France.
  • Salamé E; Department of Digestive, Oncological, Endocrine, Hepato-Biliary, Pancreatic and Liver Transplant Surgery, Trousseau Hospital, Tours, France.
  • Ouaïssi M; Department of Digestive, Oncological, Endocrine, Hepato-Biliary, Pancreatic and Liver Transplant Surgery, Trousseau Hospital, Tours, France m.ouaissi@chu-tours.fr.
Anticancer Res ; 39(9): 5105-5113, 2019 Sep.
Article em En | MEDLINE | ID: mdl-31519622
ABSTRACT
BACKGROUND/

AIM:

Preoperative radiochemotherapy (RCT) followed by total mesorectum excision has become the gold standard for locally advanced carcinoma of the low and middle rectum. The aim of the study is to evaluate the short and long-term outcomes of patients in complete pathological response (PR) following this treatment sequence. PATIENTS AND

METHODS:

One hundred and thirty patients were retrospectively included between 2005 and 2017 in an expert centre, with 3 groups formed, according to the PR i) complete PR (absence of tumour cells on the surgical specimen ypT0N0), ii) partial PR (T or N downsizing) and iii) without PR.

RESULTS:

The complete PR rate was 13.1%. The complete PR group tended to develop less symptomatic fistulas compared to partial PR and without PR groups (5.8% versus 13.5% versus 18.7, respectively; p=0.607). The 5-year disease-free survival was increased for complete-PR patients (93% versus 79% versus 47%, respectively; p=0.0003) without an improvement in overall survival.

CONCLUSION:

Complete PR is associated with an improvement in survival without recurrence and without an improvement in the overall survival at 5 years.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais Tipo de estudo: Diagnostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais Tipo de estudo: Diagnostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article