Plasma and cerebrospinal fluid pharmacokinetics of hydroxysafflor yellow A in patients with traumatic brain injury after intravenous administration of Xuebijing using LC-MS/MS method.
Xenobiotica
; 50(5): 545-551, 2020 May.
Article
em En
| MEDLINE
| ID: mdl-31524030
ABSTRACT
Hydroxysafflor yellow A (HSYA) is the most pharmaceutically relevant compound in Xuebijing (XBJ) for traumatic brain injury (TBI) treatment. We aimed to investigate biofluids pharmacokinetics of HSYA from XBJ to ensure the drug safety and to guide the clinical use.A sensitive, rapid and reliable liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was applied to investigate pharmacokinetics of HSYA in TBI patients after intravenous administration of XBJ. Non-compartmental methods using DAS 3.0 software were applied to analyse the pharmacokinetic parameters.A similar half-life (Plasmat1/2 14.55 ± 3.51 h vs. CSFt1/2 15.73 ± 3.63) was observed. HSYA reached the peak level rapidly, but exhibited a strongly slow absorption phase from blood to cerebrospinal fluid (CSF, PlasmaTmax 0.69 ± 0.26 h vs. CSFTmax 4.0 ± 2.62 h). HSYA exhibited much higher Cmax (PlasmaCmax 9342.76 ± 2489.23 µg/L vs. CSFCmax 98.08 ± 14.51 µg/L) and AUC0-t (PlasmaAUC0-t 57490.5 ± 5560.3 µg h/L vs. CSFAUC0-t 1851.6 ± 269.1 µg h/L), yet a shorter CL (PlasmaCL 0.02 ± 0.002 L/h/kg vs. CSFCL 0.55 ± 0.01 L/h/kg) in plasma than in CSF. The AUCCSF/AUCplasma of HSYA was almost 3.37%.In summary, the results demonstrate that part of HSYA come across blood-brain barrier after XBJ administration. This study provides evidence for better understanding the pharmacokinetics and potential for clinical guidance of XBJ for TBI treatment.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinonas
/
Medicamentos de Ervas Chinesas
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Chalcona
/
Lesões Encefálicas Traumáticas
Tipo de estudo:
Guideline
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article