Dual role of N-acetyl-aspartyl-glutamate metabolism in cancer monitor and therapy.
Mol Cell Oncol
; 6(5): e1627273, 2019.
Article
em En
| MEDLINE
| ID: mdl-31528698
ABSTRACT
We uncovered the neurotransmitter N-acetyl-aspartyl-glutamate (NAAG) as a reservoir providing glutamate to promote cancer growth, and demonstrated that inhibition of NAAG hydrolysis by targeting glutamate carboxypeptidase II is a viable strategy for cancer therapy. Our study also suggests that NAAG concentration in plasma could be a non-invasive measurement to monitor cancer progression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article