T-cell depleted HLA-haploidentical HSCT in a child with neuromyelitis optica.
Ann Clin Transl Neurol
; 6(10): 2110-2113, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-31529689
ABSTRACT
Neuromyelitis optica is an immune-mediated disease characterized by a relapsing course, resulting in progressive disability. In children, given the long life expectancy, a disease-modifying treatment could be particularly desirable. Unfortunately, the currently available treatment strategies with this potential are scarce. Very limited data are available about the use of allogeneic hematopoietic stem cell transplantation (HSCT) for autoimmune neurological diseases. In this report, we present a pediatric case successfully treated with allogeneic HSCT from an HLA-haploidentical donor, after ex vivo TCR/CD19-depletion of the graft. To the best of our knowledge, this is the first case of a pediatric patient to benefit from such a treatment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos T
/
Depleção Linfocítica
/
Neuromielite Óptica
/
Transplante de Células-Tronco Hematopoéticas
/
Antígenos CD19
/
Transplante Haploidêntico
Limite:
Child
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article