Your browser doesn't support javascript.
loading
A new bile acid from the traditional chinese medicine shedan.
Yuan, Yan; Wang, Qiu-Yan; Zhang, Jie; Nie, Jing; Zhou, Cheng-Gao; Yi, Wen-Qin; Wan, Luo-Sheng; Chen, Jia-Chun.
Afiliação
  • Yuan Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Wang QY; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Zhang J; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Nie J; Hubei Institute for Drug Control, Wuhan 430075, China.
  • Zhou CG; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Yi WQ; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Wan LS; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Chen JC; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
J Asian Nat Prod Res ; 22(9): 879-885, 2020 Sep.
Article em En | MEDLINE | ID: mdl-31535572
A new bile acid tauro-16ß-hydroxy-12α-sulfate-5ß-cholenoic acid (1), along with six known ones (2-7), was isolated from the snake bile. Its planar structure and relative configuration were elucidated based on extensive spectroscopic analyses. Moreover, compound 2 showed inhibitory effect on NO production in RAW 264.7 macrophages at non-cytotoxic concentration (20 µM) with inhibitory rate of 69.7%. [Formula: see text].
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bile / Medicina Tradicional Chinesa Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bile / Medicina Tradicional Chinesa Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article