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Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples.
Seidler, Paul Matthew; Boyer, David R; Murray, Kevin A; Yang, Tianxiao P; Bentzel, Megan; Sawaya, Michael R; Rosenberg, Gregory; Cascio, Duilio; Williams, Christopher Kazu; Newell, Kathy L; Ghetti, Bernardino; DeTure, Michael A; Dickson, Dennis W; Vinters, Harry V; Eisenberg, David S.
Afiliação
  • Seidler PM; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, University of California, Los Angeles, California 90095.
  • Boyer DR; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, University of California, Los Angeles, California 90095.
  • Murray KA; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, University of California, Los Angeles, California 90095.
  • Yang TP; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, University of California, Los Angeles, California 90095.
  • Bentzel M; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, University of California, Los Angeles, California 90095.
  • Sawaya MR; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, University of California, Los Angeles, California 90095.
  • Rosenberg G; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, University of California, Los Angeles, California 90095.
  • Cascio D; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, University of California, Los Angeles, California 90095.
  • Williams CK; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, California 90095.
  • Newell KL; Indiana University School of Medicine, Indianapolis, Indiana 46202.
  • Ghetti B; Indiana University School of Medicine, Indianapolis, Indiana 46202.
  • DeTure MA; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224.
  • Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224.
  • Vinters HV; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, California 90095.
  • Eisenberg DS; Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles, California 90095.
J Biol Chem ; 294(44): 16451-16464, 2019 11 01.
Article em En | MEDLINE | ID: mdl-31537646

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas tau / Tauopatias / Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas tau / Tauopatias / Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article