Factors associated with skin cancer in lung transplant recipients: A single-center experience.
Clin Transplant
; 33(12): e13718, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-31545540
ABSTRACT
BACKGROUND:
Skin cancer is common after solid organ transplantation, but few have investigated it after lung transplant (LTx).OBJECTIVE:
We assessed incidence and predictors of non-melanoma skin cancer (NMSC) post-LTx.METHODS:
We studied patients who underwent LTx at our center from 2012 to 2015.RESULTS:
Of 287 patients, mean age was 59.6 ± 11 years, 170 (59.2%) were men, and 231 (80.5%) were white. Seventy-six (26.5%) developed NMSC over a median follow-up of 32 months (IQR, 23-45). Of those with NMSC, 37% developed subsequent skin cancer of the same type. Independent predictors of decreased odds of NMSC and squamous cell carcinoma (SCC) were non-white race (P = .002; P = .003) and body mass index >30 kg/m2 compared with underweight patients (P = .001, P = .009). Patients with skin cancer pre-LTx had higher risk of post-LTx skin cancer (P = .02). Voriconazole use ≥100 days was associated with increased risk of SCC (P = .03), but not increased risk of basal cell carcinoma. Out of 76, 4 (5.3%) died from skin cancer.LIMITATIONS:
Retrospective, single-center study.CONCLUSION:
Squamous cell carcinoma risk post-LTx may increase with prolonged voriconazole use in white patients with pre-LTx history of skin cancer, whereas excess body weight may be protective from NMSC. Regular pre- and post-LTx skin cancer screenings and guidelines are warranted.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
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Neoplasias Cutâneas
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Carcinoma Basocelular
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Carcinoma de Células Escamosas
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Transplante de Pulmão
/
Rejeição de Enxerto
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Female
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Humans
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Male
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Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article