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Hydrogel-Mediated DOX⋅HCl/PTX Delivery System for Breast Cancer Therapy.
Hyun, Hoon; Yoo, Young Bum; Kim, So Yeon; Ko, Hyun Sun; Chun, Heung Jae; Yang, Dae Hyeok.
Afiliação
  • Hyun H; Department of Biomedical, Chonnam National University Medical School, Gwangju 61469, Korea. hhyun@chonnam.ac.kr.
  • Yoo YB; Department of Surgery, School of Medicine, Konkuk University, Seoul 05030, Korea. 0117652771@kuh.ac.kr.
  • Kim SY; Department of Dental Hygiene, College of Health Sciences, Cheongju University, Cheongju 28503, Korea. goodany00@gmail.com.
  • Ko HS; Department of Obstetrics & Gynecology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. mongkoko@catholic.ac.kr.
  • Chun HJ; Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. chunhj@catholic.ac.kr.
  • Yang DH; Institute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. chunhj@catholic.ac.kr.
Int J Mol Sci ; 20(19)2019 Sep 20.
Article em En | MEDLINE | ID: mdl-31547111
We used a hydrogel-mediated dual drug delivery approach, based on an injectable glycol chitosan (GC) hydrogel, doxorubicin hydrochloride (DOX⋅HCl), and a complex of beta-cyclodextrin (ß-CD) and paclitaxel (PTX) (GDCP) for breast cancer therapy in vitro and in vivo. The hydrogel was swollen over 3 days and remained so thereafter. After an initial burst period of 7 hours, the two drugs were released in a sustained manner for 7 days. The in vitro cell viability test showed that GDCP had a better anticancer effect than well plate and DOX⋅HCl/PTX (DP). In addition, the in vivo tests, which evaluated the anticancer effect, systemic toxicity, and histology, proved the feasibility of GDCP as a clinical therapy for breast cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Doxorrubicina / Sistemas de Liberação de Medicamentos / Paclitaxel / Hidrogéis Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Doxorrubicina / Sistemas de Liberação de Medicamentos / Paclitaxel / Hidrogéis Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article