iPSC-derived MSC therapy induces immune tolerance and supports long-term graft survival in mouse orthotopic tracheal transplants.

Khan, Mohammad Afzal; Alanazi, Fatimah; Ahmed, Hala Abdalrahman; Shamma, Talal; Kelly, Kilian; Hammad, Mohamed A; Alawad, Abdullah O; Assiri, Abdullah Mohammed; Broering, Dieter Clemens

Khan, Mohammad Afzal; Alanazi, Fatimah; Ahmed, Hala Abdalrahman; Shamma, Talal; Kelly, Kilian; Hammad, Mohamed A; Alawad, Abdullah O; Assiri, Abdullah Mohammed; Broering, Dieter Clemens.

Afiliação

Khan MA; Organ Transplant Research Section, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia. mkhan26@kfshrc.edu.sa.
Alanazi F; Organ Transplant Research Section, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
Ahmed HA; Comparative Medicine Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
Shamma T; Organ Transplant Research Section, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
Kelly K; Cynata Therapeutics Limited, Melbourne, Australia.
Hammad MA; National Center for Stem Cell Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Alawad AO; National Center for Stem Cell Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Assiri AM; Comparative Medicine Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
Broering DC; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

Stem Cell Res Ther ; 10(1): 290, 2019 09 23.

Article em En | MEDLINE | ID: mdl-31547869

Assuntos

Rejeição de Enxerto/terapia; Sobrevivência de Enxerto; Transplante de Células-Tronco Mesenquimais/métodos; Transplante de Órgãos/métodos; Traqueia/transplante; Tolerância ao Transplante; Animais; Células Cultivadas; Rejeição de Enxerto/imunologia; Células-Tronco Pluripotentes Induzidas/citologia; Células-Tronco Pluripotentes Induzidas/imunologia; Células-Tronco Mesenquimais/citologia; Células-Tronco Mesenquimais/imunologia; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Transplante de Órgãos/efeitos adversos; Linfócitos T Reguladores/imunologia

Palavras-chave

Hypoxia and ischemia; Immunotolerance; Microvasculature; Orthotopic tracheal transplants; Regulatory T cells; Stem cell therapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traqueia / Transplante de Órgãos / Tolerância ao Transplante / Transplante de Células-Tronco Mesenquimais / Rejeição de Enxerto / Sobrevivência de Enxerto Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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