miR-125b acts as anti-fibrotic therapeutic target through regulating Gli3 in vivo and in vitro.

Hu, Zongqiang; Li, Li; Ran, Jianghua; Chu, Guang; Gao, Hongqiang; Guo, Licheng; Chen, Jiapeng

Hu, Zongqiang; Li, Li; Ran, Jianghua; Chu, Guang; Gao, Hongqiang; Guo, Licheng; Chen, Jiapeng.

Afiliação

Hu Z; Department of Hepatobiliary Surgery, The First People's Hospital of Kunming City & Galmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Li L; Department of Hepatobiliary Surgery, The First People's Hospital of Kunming City & Galmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. Electronic address: li_li_hep@163.com.
Ran J; Department of Hepatobiliary Surgery, The First People's Hospital of Kunming City & Galmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Chu G; Department of Hepatobiliary Surgery, The First People's Hospital of Kunming City & Galmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Gao H; Department of Hepatobiliary Surgery, The First People's Hospital of Kunming City & Galmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Guo L; Department of Hepatobiliary Surgery, Da Ban Qiao Township Public Health Center of Guandu District, Kunming, Yunnan, China.
Chen J; Department of Hepatobiliary Surgery, Da Ban Qiao Township Public Health Center of Guandu District, Kunming, Yunnan, China.

Ann Hepatol ; 18(6): 825-832, 2019.

Article em En | MEDLINE | ID: mdl-31548167

Assuntos

Cirrose Hepática Experimental/genética; Cirrose Hepática/genética; MicroRNAs/genética; Proteínas do Tecido Nervoso/genética; Proteína Gli3 com Dedos de Zinco/genética; Actinas/genética; Actinas/metabolismo; Albuminas/metabolismo; Animais; Tetracloreto de Carbono/toxicidade; Estudos de Casos e Controles; Células HEK293; Humanos; Técnicas In Vitro; Cirrose Hepática/metabolismo; Cirrose Hepática Experimental/induzido quimicamente; Cirrose Hepática Experimental/metabolismo; Cirrose Hepática Experimental/patologia; Masculino; MicroRNAs/metabolismo; Proteínas do Tecido Nervoso/metabolismo; Ratos; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Células THP-1; Proteína Gli3 com Dedos de Zinco/metabolismo

Palavras-chave

Gli3; Liver fibrosis; Liver fibrosis suppression; Mir125b

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Proteína Gli3 com Dedos de Zinco / Cirrose Hepática / Cirrose Hepática Experimental / Proteínas do Tecido Nervoso Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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