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D-dimer level and long-term outcome in patients with end-stage heart failure secondary to idiopathic dilated cardiomyopathy.
Huang, Bi; Li, Yuan-Jing; Shen, Jian; Yang, Yuan; Liu, Gang; Luo, Su-Xin.
Afiliação
  • Huang B; Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Li YJ; Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Shen J; Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Yang Y; Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Liu G; Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Luo SX; Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
J Geriatr Cardiol ; 16(8): 621-629, 2019 Aug.
Article em En | MEDLINE | ID: mdl-31555330
BACKGROUND: Previous studies had demonstrated hemostatic abnormalities in patients with heart failure (HF) and several studies have shown that abnormal coagulation indices, represented by elevated D-dimer, had prognostic significance in patients with compatible or acute decompensated HF. However, the impact of D-dimer on the outcome in patients with end-stage HF remains unclear. METHODS: A total of 244 consecutive patients with end-stage HF due to idiopathic dilated cardiomyopathy (DCM) were prospectively enrolled from February 2011 to September 2014. D-dimer levels were measured and its prognostic value was assessed. Primary endpoint was all-cause mortality during the follow-up period. Secondary endpoints were stroke, bleeding, occurrence of sustained ventricular tachycardia or ventricular fibrillation, and major adverse cardiovascular events (MACE). RESULTS: D-dimer was significantly elevated in the non-survivors (median: 0.8 vs. 1.1 mg/L, P < 0.001). Traditional markers including B-type natriuretic peptide, troponin I, left ventricular ejection fraction, and left ventricular end-diastolic dimension provided limited prognostic value; but the addition of D-dimer refined the risk stratification. The optimal cut-off value of D-dimer to predict all-cause mortality was 0.84 mg/L by receiver operator characteristic analysis. Elevated D-dimer level was independently associated with increased risk of long-term all-cause mortality (HR = 2.315, 95% CI: 1.570-3.414, P < 0.001) and MACE (HR = 1.256, 95% CI: 1.058-1.490, P = 0.009), and the predictive value was independent of age, sex, atrial fibrillation and anticoagulation status. CONCLUSIONS: Elevated D-dimer level was independently associated with poor long-term outcome in patients with end-stage HF secondary to idiopathic DCM, and the predictive value was superior to that of traditional prognostic markers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2019 Tipo de documento: Article