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Successful treatment of post-transplant CMV meningoencephalitis with third-party CMV virus-specific T cells: Lessons learned.
Alonso, Laura; Rudilla, Francesc; Gimeno, Ramón; Codinach, Margarita; Blanco, Margarita; Querol, Sergio; Diaz de Heredia, Cristina.
Afiliação
  • Alonso L; Department of Pediatric Hematology and Oncology, Hospital Universitario Vall d'Hebron, Barcelona, Spain.
  • Rudilla F; Histocompatibility and Immunogenetics Laboratory, Banc de Sang I Teixits, Cell Therapy Unit, Banc de Sang i Teixits, Barcelona, Spain.
  • Gimeno R; Transfusional Medicine Group, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Codinach M; IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
  • Blanco M; Banc de Sang i Teixits, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain.
  • Querol S; Banc de Sang i Teixits, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain.
  • Diaz de Heredia C; Banc de Sang i Teixits, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain.
Pediatr Transplant ; 23(8): e13584, 2019 12.
Article em En | MEDLINE | ID: mdl-31556188
ABSTRACT
Cytomegalovirus encephalitis is a challenging life-threatening complication following hematopoietic stem cell transplantation for which medical treatment is usually ineffective or toxic. However, in recent years, adoptive T-cell therapy has been reported to provide a significant chance of cure for patients with viral infections. Herein, two cases of pediatric patients successfully treated with third-party donor-derived virus-specific T cells for CMV meningoencephalitis are reported.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Pós-Operatórias / Imunoterapia Adotiva / Infecções por Citomegalovirus / Transplante de Células-Tronco Hematopoéticas / Meningoencefalite Limite: Child / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Pós-Operatórias / Imunoterapia Adotiva / Infecções por Citomegalovirus / Transplante de Células-Tronco Hematopoéticas / Meningoencefalite Limite: Child / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article