Learning how to interpret 'dangerous' internal standard behaviors.
Bioanalysis
; 11(18): 1679-1684, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31556306
ABSTRACT
Internal standard (IS) response has been an active topic of discussion within the bioanalytical community. Initial discussions focused on developing criteria for anomalous responses. Recently, understanding the cause and potential impact of variable IS response has been emphasized. Following a review of recommendations from industry discussions regarding variable IS responses, case studies where interferences with IS response resulted in quantitation inaccuracy are presented. The examples illustrate that variable IS response cannot always be attributed to compensation of matrix effects. Anomalous IS responses, even for stable label internal standards should be investigated and the root cause for the anomalous behavior should, if possible, be determined.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Técnicas de Química Analítica
/
Interpretação Estatística de Dados
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article