Changes in the Regulatory T-Lymphocyte Counts in HIV-Infected Patients with a Discordant Response to Antiretroviral Therapy.
Dokl Biol Sci
; 487(1): 128-131, 2019 Jul.
Article
em En
| MEDLINE
| ID: mdl-31571082
ABSTRACT
We examined HIV-infected patients with different efficacies of immune system restoration during antiretroviral therapy. The study showed that against the background of low CD4+ T cell counts, subjects with a discordant immunologic response (patients with <350 CD4+ T cells per µL of blood after more than two years of treatment) develop a regulatory CD4+ T cell (Treg) deficiency. Furthermore, in these patients, the immunodeficiency is accompanied by an increase in the Treg frequency. Accumulation of regulatory T lymphocytes in the blood of HIVinfected subjects with discordant response to the treatment indicates a high viability of this T cell subset.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Linfócitos T Reguladores
/
Fármacos Anti-HIV
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article