Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions.
Chem Commun (Camb)
; 55(91): 13653-13656, 2019 Nov 12.
Article
em En
| MEDLINE
| ID: mdl-31593201
ABSTRACT
Blending synthetic biology and synthetic chemistry represents a powerful approach to diversity complex molecules. To further enable this, compatible synthetic tools are needed. We report the first Buchwald Hartwig amination reactions with unprotected halotryptophans under aqueous conditions and demonstrate this methodology is applicable also to the modification of unprotected tripeptides and the natural product barettin.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Peptídeos Cíclicos
/
Triptofano
/
Água
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article