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Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions.
Renault, Yohann J G; Lynch, Rosemary; Marelli, Enrico; Sharma, Sunil V; Pubill-Ulldemolins, Cristina; Sharp, Joshua A; Cartmell, Christopher; Cárdenas, Paco; Goss, Rebecca J M.
Afiliação
  • Renault YJG; Department of Chemistry & BSRC University of St Andrews St Andrews, KY16 9ST, UK. rjmg@st-andrews.ac.uk.
  • Lynch R; Department of Chemistry & BSRC University of St Andrews St Andrews, KY16 9ST, UK. rjmg@st-andrews.ac.uk.
  • Marelli E; Department of Chemistry & BSRC University of St Andrews St Andrews, KY16 9ST, UK. rjmg@st-andrews.ac.uk.
  • Sharma SV; Department of Chemistry & BSRC University of St Andrews St Andrews, KY16 9ST, UK. rjmg@st-andrews.ac.uk.
  • Pubill-Ulldemolins C; Department of Chemistry & BSRC University of St Andrews St Andrews, KY16 9ST, UK. rjmg@st-andrews.ac.uk and Department of Chemistry, School of Life Sciences, University of Sussex, Brighton, BN19QJ, UK.
  • Sharp JA; Department of Chemistry & BSRC University of St Andrews St Andrews, KY16 9ST, UK. rjmg@st-andrews.ac.uk.
  • Cartmell C; Department of Chemistry & BSRC University of St Andrews St Andrews, KY16 9ST, UK. rjmg@st-andrews.ac.uk.
  • Cárdenas P; Department of Medicinal Chemistry, Uppsala University, Uppsala 75123, Sweden.
  • Goss RJM; Department of Chemistry & BSRC University of St Andrews St Andrews, KY16 9ST, UK. rjmg@st-andrews.ac.uk.
Chem Commun (Camb) ; 55(91): 13653-13656, 2019 Nov 12.
Article em En | MEDLINE | ID: mdl-31593201
ABSTRACT
Blending synthetic biology and synthetic chemistry represents a powerful approach to diversity complex molecules. To further enable this, compatible synthetic tools are needed. We report the first Buchwald Hartwig amination reactions with unprotected halotryptophans under aqueous conditions and demonstrate this methodology is applicable also to the modification of unprotected tripeptides and the natural product barettin.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Peptídeos Cíclicos / Triptofano / Água Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Peptídeos Cíclicos / Triptofano / Água Idioma: En Ano de publicação: 2019 Tipo de documento: Article