Your browser doesn't support javascript.
loading
Squamous differentiation portends poor prognosis in low and intermediate-risk endometrioid endometrial cancer.
Andrade, Diocesio Alves Pinto de; da Silva, Vinicius Duval; Matsushita, Graziela de Macedo; de Lima, Marcos Alves; Vieira, Marcelo de Andrade; Andrade, Carlos Eduardo Mattos Cunha; Schmidt, Ronaldo Luís; Reis, Rui Manuel; Dos Reis, Ricardo.
Afiliação
  • Andrade DAP; Departament of Oncology, InORP ONCOCLÍNICAS Group (Oncology Institute of Ribeirão Preto), Ribeirão Preto, São Paulo, Brazil.
  • da Silva VD; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
  • Matsushita GM; Departament of Pathology, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
  • de Lima MA; Departament of Pathology, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
  • Vieira MA; Epidemiology and Biostatistics Nucleus, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
  • Andrade CEMC; Department of Gynecologic Oncology, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
  • Schmidt RL; Department of Gynecologic Oncology, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
  • Reis RM; Department of Gynecologic Oncology, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
  • Dos Reis R; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
PLoS One ; 14(10): e0220086, 2019.
Article em En | MEDLINE | ID: mdl-31600211
ABSTRACT

BACKGROUND:

Endometrial cancer presents well-defined risk factors myometrial invasion, histological subtype, tumor grade, lymphovascular space invasion (LVSI). Some low and intermediate-risk endometrioid endometrial cancer patients exhibited unexpected outcomes. This study aimed to investigate other clinical-pathological factors that might influence the recurrence rates of patients diagnosed with low and intermediate-risk endometrioid endometrial cancer.

METHODS:

A case-control study from a cohort retrospective of 196 patients diagnosed with low and intermediate-risk endometrioid endometrial cancer at a single institution from 2009 to 2014 was conducted. Medical records were reviewed to compare clinical (race, smoking, menopause age, body mass index) and pathological (endometrioid vs endometrioid with squamous differentiation, tumor differentiation grade, tumor location, endocervical invasion, LVSI) features of patients with recurrence (case) and without recurrence (control) of disease. Three controls for each case were matched for age and staging.

RESULTS:

Twenty-one patients with recurrence were found (10.7%), of which 14 were stage IA, and 7 were stage IB. In accordance, 63 patients without recurrence were selected as controls. There were no significant differences in any clinical characteristics between cases and controls. Among pathological variables, presence of squamous differentiation (28.6% vs. 4.8%, p = 0.007), tumor differentiation grade 2 or 3 (57.1% vs. 30.2%, p = 0.037) and presence of endocervical invasion (28.6% vs. 12.7%, p = 0.103) were associated with disease recurrence on a univariate analysis. On multivariable analysis, only squamous differentiation was a significant risk factor for recurrence (p = 0.031).

CONCLUSION:

Our data suggest that squamous differentiation may be an adverse prognostic factor in patients with low and intermediate-risk endometrioid endometrial cancer, that showed a 5.6-fold increased risk for recurrence.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio / Carcinoma Endometrioide Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio / Carcinoma Endometrioide Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article