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Chromosome errors in human eggs shape natural fertility over reproductive life span.
Gruhn, Jennifer R; Zielinska, Agata P; Shukla, Vallari; Blanshard, Robert; Capalbo, Antonio; Cimadomo, Danilo; Nikiforov, Dmitry; Chan, Andrew Chi-Ho; Newnham, Louise J; Vogel, Ivan; Scarica, Catello; Krapchev, Marta; Taylor, Deborah; Kristensen, Stine Gry; Cheng, Junping; Ernst, Erik; Bjørn, Anne-Mette Bay; Colmorn, Lotte Berdiin; Blayney, Martyn; Elder, Kay; Liss, Joanna; Hartshorne, Geraldine; Grøndahl, Marie Louise; Rienzi, Laura; Ubaldi, Filippo; McCoy, Rajiv; Lukaszuk, Krzysztof; Andersen, Claus Yding; Schuh, Melina; Hoffmann, Eva R.
Afiliação
  • Gruhn JR; DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Zielinska AP; Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany.
  • Shukla V; DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Blanshard R; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.
  • Capalbo A; Illumina Inc., Fulbourn, UK.
  • Cimadomo D; Igenomix, Marostica, Italy.
  • Nikiforov D; G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197 Rome, Italy.
  • Chan AC; Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Newnham LJ; Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy.
  • Vogel I; DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Scarica C; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.
  • Krapchev M; DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Taylor D; DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy.
  • Kristensen SG; INVICTA Fertility and Reproductive Center, Gdansk, Poland.
  • Cheng J; Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK.
  • Ernst E; Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Bjørn AB; Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Colmorn LB; Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark.
  • Blayney M; Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark.
  • Elder K; The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark.
  • Liss J; Bourn Hall Clinic, Cambridge, UK.
  • Hartshorne G; Bourn Hall Clinic, Cambridge, UK.
  • Grøndahl ML; INVICTA Fertility and Reproductive Center, Gdansk, Poland.
  • Rienzi L; Department of Biology and Medical Genetics, University of Gdansk, Gdansk, Poland.
  • Ubaldi F; Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK.
  • McCoy R; Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark.
  • Lukaszuk K; G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197 Rome, Italy.
  • Andersen CY; G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197 Rome, Italy.
  • Schuh M; Department of Biology, Johns Hopkins University, Baltimore, MD, USA.
  • Hoffmann ER; INVICTA Fertility and Reproductive Center, Gdansk, Poland.
Science ; 365(6460): 1466-1469, 2019 09 27.
Article em En | MEDLINE | ID: mdl-31604276
ABSTRACT
Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oócitos / Envelhecimento / Segregação de Cromossomos / Fertilidade / Aneuploidia Limite: Adolescent / Adult / Child / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oócitos / Envelhecimento / Segregação de Cromossomos / Fertilidade / Aneuploidia Limite: Adolescent / Adult / Child / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article