Allergic disease and low ASQ communication score in children.
Brain Behav Immun
; 83: 293-297, 2020 01.
Article
em En
| MEDLINE
| ID: mdl-31606476
ABSTRACT
Autism Spectrum Disorders (ASD) are complex and multifactorial. Previous investigations have revealed associations between allergic disease and ASD, which are characterized by impaired communication skills. In this study we observed an association between allergic disease and communication skills development as assessed by the Ages and Stages Questionnaire (ASQ) communication score, as a proxy for ASD, among children who participated in the Vitamin D Antenatal Asthma Reduction Trial (VDAART). In particular, we observed significant associations between both a diagnosis of eczema at age 3â¯years (ORâ¯=â¯1.87; confidence interval [CI] 0.97-3.47; pâ¯=â¯0.054) and a diagnosis of food allergy at age 6â¯years (ORâ¯=â¯3.61; 95% CI 1.18-9.85; pâ¯=â¯0.015) with ASQ communication score. Plasma metabolomics analyses suggest that dysregulated tryptophan metabolism may contribute to the pathogenesis of these co-morbidities.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comunicação
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Eczema
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Transtorno do Espectro Autista
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Hipersensibilidade Alimentar
Tipo de estudo:
Qualitative_research
Limite:
Child
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Child, preschool
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Female
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Humans
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Male
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Pregnancy
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article