Comparative in vitro activity of bacteriophage endolysin HY-133 against Staphylococcus aureus attached to vascular graft surface.
Med Microbiol Immunol
; 209(1): 51-57, 2020 Feb.
Article
em En
| MEDLINE
| ID: mdl-31624909
ABSTRACT
Novel strategies are needed for combating Staphylococcus aureus biofilm in vascular graft infections. We investigated the in vitro activity of bacteriophage endolysin HY-133, daptomycin and rifampin against S. aureus attached to vascular graft surface. Daptomycin showed rapid bactericidal effect on surface-associated S. aureus, while the activity of HY-133 on graft surface-adherent cells was moderate and rifampin did not achieve bactericidal effect. Even in the highest concentrations, all antimicrobials used failed in a complete eradication of the surface-adherent bacteria.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endopeptidases
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Infecções Estafilocócicas
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Staphylococcus aureus
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Bacteriófagos
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Vasculite
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article