Polygenic risk scores for prostate cancer: testing considerations.
Can J Urol
; 26(5 Suppl 2): 17-18, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-31629419
ABSTRACT
Genome-wide association studies (GWAS) have identified more than 170 single nucleotide variants (SNVs) associated with prostate cancer risk. Each variant is associated with only small increases in risk and is not predictive of an individuals' overall risk of developing prostate cancer. Polygenic risk scores (PRS) combining these variants are now clinically available and may improve predictive value of other factors such as PSA. This overview reviews the current state of PRS for prostate cancer including testing considerations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Testes Genéticos
/
Herança Multifatorial
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article