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A glucose-depleting silica nanosystem for increasing reactive oxygen species and scavenging glutathione in cancer therapy.
Ong, Wee Kong; Jana, Deblin; Zhao, Yanli.
Afiliação
  • Ong WK; Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore. zhaoyanli@ntu.edu.sg.
  • Jana D; Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore. zhaoyanli@ntu.edu.sg.
  • Zhao Y; Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore. zhaoyanli@ntu.edu.sg.
Chem Commun (Camb) ; 55(89): 13374-13377, 2019 Nov 18.
Article em En | MEDLINE | ID: mdl-31633705
ABSTRACT
Cancer cells adapt to cellular oxidative stress by increasing glutathione (GSH). An organically modified silica nanosystem (ORMOSIL@GOx) was fabricated to achieve a lethal level of oxidative stress in cancer cells by depleting intracellular GSH while increasing reactive oxygen species.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espécies Reativas de Oxigênio / Compostos de Organossilício / Nanopartículas / Glucose / Glutationa / Neoplasias / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espécies Reativas de Oxigênio / Compostos de Organossilício / Nanopartículas / Glucose / Glutationa / Neoplasias / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article