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Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme.
Yang, Gloria; Anderson, Dave W; Baier, Florian; Dohmen, Elias; Hong, Nansook; Carr, Paul D; Kamerlin, Shina Caroline Lynn; Jackson, Colin J; Bornberg-Bauer, Erich; Tokuriki, Nobuhiko.
Afiliação
  • Yang G; Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
  • Anderson DW; Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
  • Baier F; Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada.
  • Dohmen E; Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
  • Hong N; Institute for Evolution and Biodiversity, Evolutionary Bioinformatics, Westfälische Wilhelms University, Münster, Germany.
  • Carr PD; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia.
  • Kamerlin SCL; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia.
  • Jackson CJ; Science for Life Laboratory, Department of Chemistry - BMC, Uppsala University, Uppsala, Sweden.
  • Bornberg-Bauer E; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia.
  • Tokuriki N; Institute for Evolution and Biodiversity, Evolutionary Bioinformatics, Westfälische Wilhelms University, Münster, Germany.
Nat Chem Biol ; 15(11): 1120-1128, 2019 11.
Article em En | MEDLINE | ID: mdl-31636435
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Xenobióticos / Epistasia Genética / Hidrolases / Metil Paration Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Xenobióticos / Epistasia Genética / Hidrolases / Metil Paration Idioma: En Ano de publicação: 2019 Tipo de documento: Article