[Comparison between approximate entropy and regional homogeneity for identification of irritable bowel syndrome based on functional magnetic resonance imaging].

ABSTRACT

OBJECTIVE: To compare the effectiveness and sensitivity of entropy and regional homogeneity (ReHo) for identifying irritable bowel syndrome (IBS) based on functional magnetic resonance imaging (fMRI). METHODS: Voxel-based approximate entropy (ApEn) was calculated based on findings of resting fMRI of 54 patients with IBS and 54 healthy control subjects. Feature selection was performed using independent sample t-test, and support vector machine was then used to classify and identify different groups. The classification performance obtained from ApEn was compared with that from ReHo. RESULTS: Significant differences between the two groups were found in the left triangle part of inferior prefrontal gyrus, right angular gyrus of the inferior parietal lobule, left inferior temporal gyrus, left middle temporal gyrus, left lingual gyrus, bilateral middle occipital gyrus and bilateral superior occipital gyrus for ReHo (P < 0.05), and in the bilateral postcentral gyrus, right precentral gyrus, right inferior temporal gyrus, bilateral middle temporal gyrus and left superior occipital gyrus for ApEn (P < 0.05). ApEn consistently showed better performance than ReHo regardless of the variations in the number of features. The classification accuracy, specificity and sensitivity of ApEn were 93.5185%, 90.7407% and 96.2963%, respectively, as compared with 86.1111%, 85.1852% and 87.037% of ReHo. CONCLUSIONS: Entropy analysis based on fMRI can be more sensitive and effective than ReHo for identification of IBS.