Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds.

Hull, Christina M; Genge, Christine E; Hobbs, Yuki; Rayani, Kaveh; Lin, Eric; Gunawan, Marvin; Shafaattalab, Sanam; Tibbits, Glen F; Claydon, Tom W

Hull, Christina M; Genge, Christine E; Hobbs, Yuki; Rayani, Kaveh; Lin, Eric; Gunawan, Marvin; Shafaattalab, Sanam; Tibbits, Glen F; Claydon, Tom W.

Afiliação

Hull CM; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Genge CE; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Hobbs Y; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Rayani K; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Lin E; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Gunawan M; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Shafaattalab S; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Tibbits GF; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Claydon TW; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.

Am J Physiol Regul Integr Comp Physiol ; 317(6): R921-R931, 2019 12 01.

Article em En | MEDLINE | ID: mdl-31664867

Assuntos

Canais de Potássio Éter-A-Go-Go/metabolismo; Coração/fisiologia; Bloqueadores dos Canais de Potássio/farmacologia; Proteínas de Peixe-Zebra/metabolismo; Animais; Clorobenzenos/farmacologia; Cresóis/farmacologia; Canais de Potássio Éter-A-Go-Go/genética; Regulação da Expressão Gênica/efeitos dos fármacos; Antagonistas não Sedativos dos Receptores H1 da Histamina/farmacologia; Oócitos/efeitos dos fármacos; Oócitos/metabolismo; Fenetilaminas/farmacologia; Compostos de Fenilureia/farmacologia; Piperidinas/farmacologia; Quinolinas/farmacologia; Sulfonamidas/farmacologia; Terfenadina/farmacologia; Xenopus laevis; Peixe-Zebra; Proteínas de Peixe-Zebra/genética; ortoaminobenzoatos/farmacologia

Palavras-chave

activators; hERG; optical mapping; zERG; zebrafish; zkcnh6

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Peixe-Zebra / Bloqueadores dos Canais de Potássio / Canais de Potássio Éter-A-Go-Go / Coração Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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