A Lethal Aerosol Exposure Model of Nipah Virus Strain Bangladesh in African Green Monkeys.
J Infect Dis
; 221(Suppl 4): S431-S435, 2020 05 11.
Article
em En
| MEDLINE
| ID: mdl-31665351
ABSTRACT
The high case-fatality rates and potential for use as a biological weapon make Nipah virus (NiV) a significant public health concern. Previous studies assessing the pathogenic potential of NiV delivered by the aerosol route in African green monkeys (AGMs) used the Malaysia strain (NiVM), which has caused lower instances of respiratory illness and person-to-person transmission during human outbreaks than the Bangladesh strain (NiVB). Accordingly, we developed a small particle aerosol model of NiVB infection in AGMs. Consistent with other mucosal AGM models of NiVB infection, we achieved uniform lethality and disease pathogenesis reflective of that observed in humans.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus Nipah
/
Infecções por Henipavirus
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article