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Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.
Dwivedi, Om Prakash; Lehtovirta, Mikko; Hastoy, Benoit; Chandra, Vikash; Krentz, Nicole A J; Kleiner, Sandra; Jain, Deepak; Richard, Ann-Marie; Abaitua, Fernando; Beer, Nicola L; Grotz, Antje; Prasad, Rashmi B; Hansson, Ola; Ahlqvist, Emma; Krus, Ulrika; Artner, Isabella; Suoranta, Anu; Gomez, Daniel; Baras, Aris; Champon, Benoite; Payne, Anthony J; Moralli, Daniela; Thomsen, Soren K; Kramer, Philipp; Spiliotis, Ioannis; Ramracheya, Reshma; Chabosseau, Pauline; Theodoulou, Andria; Cheung, Rebecca; van de Bunt, Martijn; Flannick, Jason; Trombetta, Maddalena; Bonora, Enzo; Wolheim, Claes B; Sarelin, Leena; Bonadonna, Riccardo C; Rorsman, Patrik; Davies, Benjamin; Brosnan, Julia; McCarthy, Mark I; Otonkoski, Timo; Lagerstedt, Jens O; Rutter, Guy A; Gromada, Jesper; Gloyn, Anna L; Tuomi, Tiinamaija; Groop, Leif.
Afiliação
  • Dwivedi OP; Institute for Molecular Medicine Finland, Helsinki University, Helsinki, Finland.
  • Lehtovirta M; Institute for Molecular Medicine Finland, Helsinki University, Helsinki, Finland.
  • Hastoy B; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Chandra V; Stem Cells and Metabolism Research Program and Biomedicum Stem Cell Centre, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Krentz NAJ; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Kleiner S; Regeneron Pharmaceuticals, Tarrytown, NY, USA.
  • Jain D; Department of Experimental Medical Science, Lund University, Lund, Sweden.
  • Richard AM; Pfizer Inc., Cambridge, MA, USA.
  • Abaitua F; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Beer NL; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Grotz A; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Prasad RB; Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
  • Hansson O; Institute for Molecular Medicine Finland, Helsinki University, Helsinki, Finland.
  • Ahlqvist E; Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
  • Krus U; Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
  • Artner I; Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
  • Suoranta A; Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
  • Gomez D; Institute for Molecular Medicine Finland, Helsinki University, Helsinki, Finland.
  • Baras A; Regeneron Pharmaceuticals, Tarrytown, NY, USA.
  • Champon B; Regeneron Pharmaceuticals, Tarrytown, NY, USA.
  • Payne AJ; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Moralli D; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Thomsen SK; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Kramer P; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Spiliotis I; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Ramracheya R; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Chabosseau P; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Theodoulou A; Section of Cell Biology, Department of Medicine, Imperial College London, Imperial Centre for Translational and Experimental Medicine, Hammersmith, Hospital, London, UK.
  • Cheung R; Section of Cell Biology, Department of Medicine, Imperial College London, Imperial Centre for Translational and Experimental Medicine, Hammersmith, Hospital, London, UK.
  • van de Bunt M; Section of Cell Biology, Department of Medicine, Imperial College London, Imperial Centre for Translational and Experimental Medicine, Hammersmith, Hospital, London, UK.
  • Flannick J; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Trombetta M; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Bonora E; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
  • Wolheim CB; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Sarelin L; Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
  • Bonadonna RC; Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
  • Rorsman P; Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
  • Davies B; Folkhälsan Research Center, Helsinki, Finland.
  • Brosnan J; Department of Medicine and Surgery, University of Parma School of Medicine and Azienda Ospedaliera Universitaria of Parma, Parma, Italy.
  • McCarthy MI; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Otonkoski T; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Lagerstedt JO; Pfizer Inc., Cambridge, MA, USA.
  • Rutter GA; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Gromada J; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Gloyn AL; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK.
  • Tuomi T; Stem Cells and Metabolism Research Program and Biomedicum Stem Cell Centre, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Groop L; Department of Experimental Medical Science, Lund University, Lund, Sweden.
Nat Genet ; 51(11): 1596-1606, 2019 11.
Article em En | MEDLINE | ID: mdl-31676859
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ilhotas Pancreáticas / Diabetes Mellitus Tipo 2 / Células-Tronco Pluripotentes Induzidas / Transportador 8 de Zinco / Secreção de Insulina / Glucose Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ilhotas Pancreáticas / Diabetes Mellitus Tipo 2 / Células-Tronco Pluripotentes Induzidas / Transportador 8 de Zinco / Secreção de Insulina / Glucose Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article