Successful haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide in a child with X-linked chronic granulomatous disease: A first report in Asia.
Asian Pac J Allergy Immunol
; 40(3): 278-282, 2022 Sep.
Article
em En
| MEDLINE
| ID: mdl-31677618
ABSTRACT
BACKGROUND:
HLA-matched hematopoietic stem cell transplantation (HSCT) is the curative treatment for chronic granulomatous disease (CGD).OBJECTIVE:
To report a case of X-linked CGD with active infection successfully treated by haploidentical HSCT with post-transplant high dose cyclophosphamide (PTCY).METHODS:
A 5-year-old Thai boy with CGD was undergone for haploidentical HSCT using PTCY with correction of the phagocytic function. He presented with Chromobacterium violaceum liver abscess at the age of 9 months and experienced recurrent perianal abscess and invasive pulmonary aspergillosis even receiving antimicrobial prophylaxis. PTCY was given on day 3 and 4, after CD34+ cells infusion.RESULTS:
The peripheral blood-nucleated cell chimerism showed 100% on day 16 and remained 100%. Dihydrorhodamine (DHR) assay on day 108 and day 214 showed normal results. Currently at 22 months post HSCT, he does not receive antibiotic and anti-fungal prophylaxis.CONCLUSIONS:
Haploidentical HSCT with PTCY could be an effective treatment option for children with CGD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Células-Tronco Hematopoéticas
/
Doença Enxerto-Hospedeiro
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Doença Granulomatosa Crônica
Tipo de estudo:
Diagnostic_studies
Limite:
Child
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Child, preschool
/
Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article