Buxaustroines A-N, a Series of 17(13â18)abeo-Cycloartenol Triterpenoidal Alkaloids from Buxus austro-yunnanensis and Their Cardioprotective Activities.
J Nat Prod
; 82(11): 3111-3120, 2019 11 22.
Article
em En
| MEDLINE
| ID: mdl-31686503
ABSTRACT
Buxaustroines A-N (1-14), a series of triterpenoidal alkaloids featuring a novel 17(13â18)abeo motif, were obtained from the extract of Buxus austro-yunnanensis. Their structures were assigned based on NMR data analysis and X-ray diffraction crystallography. A putative biosynthetic pathway for one of the alkaloids from a co-isolate 15 is proposed. In the assessment of their bioactivities, some of the compounds displayed protective effects against doxorubicin-induced injury of myocardial cells. Preliminary structure-activity relationship studies of 1-14, which are based on the same skeleton, were conducted.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Cardiotônicos
/
Buxus
/
Alcaloides
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article