A meta-analysis of treatment effects of imiquimod for basal cell carcinoma.
J Cosmet Dermatol
; 19(1): 218-225, 2020 Jan.
Article
em En
| MEDLINE
| ID: mdl-31692232
ABSTRACT
OBJECTIVE:
We conducted this meta-analysis to assess the efficacy and safety of imiquimod in comparison with other treatments in patients with BCC.METHODS:
A comprehensive literature search was performed in the database of PubMed, Embase, and Web of Science. Outcomes of interest included histological/composite clearance rate, success rate, complete response rate, tumor free survival, and adverse events. Pooled risk ratio (RR) with 95% confidence intervals (CIs) using a fixed-effects or random-effects model were determined for each outcome.RESULTS:
A total of 13 studies involving 4256 patients were identified. Imiquimod was associated with significantly higher histological clearance rate (RR = 9.28, 95%CI 5.56, 15.49; P < .001) and composite clearance rate (RR = 34.24, 95%CI 21.29, 55.06; P = .001). Moreover, imiquimod also significantly increased complete response rate (RR = 3.15, 95%CI 1.55, 6.38; P = .001) but had no effect in the success rate (RR = 0.98, 95%CI 0.89, 1.08; P = .727) and probability of tumor-free survival (RR = 1.15, 95%CI 0.98, 1.35; P = .088), as compared with other treatments. There were more patients in imiquimod group who developed adverse events than in other treatment group (RR = 2.00, 95%CI 1.39, 2.88; P < .001).CONCLUSION:
This study indicated the effects of imiquimod in improving the histological/composite clearance rates as compared with other treatments. However, its treatment-related adverse events also should be noticed. Our findings supported that, imiquimod could be used as the first-choice treatment for BCC.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Carcinoma Basocelular
/
Creme para a Pele
/
Imiquimode
/
Antineoplásicos
Tipo de estudo:
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article