Proliposomes for oral delivery of total biflavonoids extract from <i>Selaginella doederleinii</i>: formulation development, optimization, and in vitro-in vivo characterization.

Chen, Bing; Wang, Xuewen; Lin, Dan; Xu, Dafen; Li, Shaoguang; Huang, Jianyong; Weng, Shaohuang; Lin, Zhen; Zheng, Yanjie; Yao, Hong; Lin, Xinhua

Proliposomes for oral delivery of total biflavonoids extract from Selaginella doederleinii: formulation development, optimization, and in vitro-in vivo characterization.

Chen, Bing; Wang, Xuewen; Lin, Dan; Xu, Dafen; Li, Shaoguang; Huang, Jianyong; Weng, Shaohuang; Lin, Zhen; Zheng, Yanjie; Yao, Hong; Lin, Xinhua.

Afiliação

Chen B; Nano Medical Technology Research Institute, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Wang X; Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Lin D; Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Xu D; Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Li S; Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Huang J; Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Weng S; Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Lin Z; Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Zheng Y; Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Yao H; Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Lin X; Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.

Int J Nanomedicine ; 14: 6691-6706, 2019.

Article em En | MEDLINE | ID: mdl-31692515

Assuntos

Antineoplásicos Fitogênicos/administração & dosagem; Biflavonoides/administração & dosagem; Lipossomos/administração & dosagem; Extratos Vegetais/administração & dosagem; Selaginellaceae/química; Administração Oral; Animais; Antineoplásicos Fitogênicos/química; Antineoplásicos Fitogênicos/farmacocinética; Biflavonoides/farmacocinética; Biflavonoides/farmacologia; Ácidos e Sais Biliares/química; Disponibilidade Biológica; Células HT29; Humanos; Lipossomos/química; Lipossomos/farmacocinética; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Oligossacarídeos/química; Extratos Vegetais/química; Ratos Sprague-Dawley; Solubilidade; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Selaginella doederleinii; antitumor; oral bioavailability; proliposomes; sodium deoxycholate

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Selaginellaceae / Biflavonoides / Lipossomos / Antineoplásicos Fitogênicos Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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