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5-(Hydroxyphenyl)-γ-Valerolactone-Sulfate, a Key Microbial Metabolite of Flavan-3-ols, Is Able to Reach the Brain: Evidence from Different in Silico, In Vitro and In Vivo Experimental Models.
Angelino, Donato; Carregosa, Diogo; Domenech-Coca, Cristina; Savi, Monia; Figueira, Inês; Brindani, Nicoletta; Jang, Saebyeol; Lakshman, Sukla; Molokin, Aleksey; Urban, Joseph F; Davis, Cindy D; Brito, Maria Alexandra; Kim, Kwang Sik; Brighenti, Furio; Curti, Claudio; Bladé, Cinta; Del Bas, Josep M; Stilli, Donatella; Solano-Aguilar, Gloria I; Santos, Claudia Nunes Dos; Del Rio, Daniele; Mena, Pedro.
Afiliação
  • Angelino D; Human Nutrition Unit, Department of Veterinary Medicine, University of Parma, 43125 Parma, Italy.
  • Carregosa D; CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.
  • Domenech-Coca C; Unitat de Nutrició i Salut, Centre Tecnològic de Catalunya, Eurecat, 43204 Reus, Spain.
  • Savi M; Department of Biochemistry and Biotechnology, Nutrigenomics Research Group, Universitat Rovira i Virgili, 43007 Tarragona, Spain.
  • Figueira I; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
  • Brindani N; Instituto de Tecnologia Química e Biológica-António Xavier, Universidade Nova de Lisboa, EAN, 2781-901 Oeiras, Portugal.
  • Jang S; Human Nutrition Unit, Department of Food and Drug, University of Parma, 43125 Parma, Italy.
  • Lakshman S; Department of Food and Drug, University of Parma, 43125 Parma, Italy.
  • Molokin A; U.S. Department of Agriculture, Northeast Area, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet Genomics and Immunology Laboratory, Beltsville, MD 20705, USA.
  • Urban JF; U.S. Department of Agriculture, Northeast Area, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet Genomics and Immunology Laboratory, Beltsville, MD 20705, USA.
  • Davis CD; U.S. Department of Agriculture, Northeast Area, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet Genomics and Immunology Laboratory, Beltsville, MD 20705, USA.
  • Brito MA; U.S. Department of Agriculture, Northeast Area, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet Genomics and Immunology Laboratory, Beltsville, MD 20705, USA.
  • Kim KS; Office of Dietary Supplements, National Institutes of Health, Bethesda, MD 20892, USA.
  • Brighenti F; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.
  • Curti C; Department of Biochemistry and Human Biology, Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.
  • Bladé C; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Del Bas JM; Human Nutrition Unit, Department of Food and Drug, University of Parma, 43125 Parma, Italy.
  • Stilli D; Department of Food and Drug, University of Parma, 43125 Parma, Italy.
  • Solano-Aguilar GI; Department of Biochemistry and Biotechnology, Nutrigenomics Research Group, Universitat Rovira i Virgili, 43007 Tarragona, Spain.
  • Santos CND; Unitat de Nutrició i Salut, Centre Tecnològic de Catalunya, Eurecat, 43204 Reus, Spain.
  • Del Rio D; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
  • Mena P; U.S. Department of Agriculture, Northeast Area, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet Genomics and Immunology Laboratory, Beltsville, MD 20705, USA.
Nutrients ; 11(11)2019 Nov 05.
Article em En | MEDLINE | ID: mdl-31694297
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfatos / Flavonoides / Barreira Hematoencefálica / Polifenóis / Lactonas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfatos / Flavonoides / Barreira Hematoencefálica / Polifenóis / Lactonas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article