Genetic Diversity of Collaborative Cross Mice Controls Viral Replication, Clinical Severity, and Brain Pathology Induced by Zika Virus Infection, Independently of <i>Oas1b</i>.

Manet, Caroline; Simon-Lorière, Etienne; Jouvion, Grégory; Hardy, David; Prot, Matthieu; Conquet, Laurine; Flamand, Marie; Panthier, Jean-Jacques; Sakuntabhai, Anavaj; Montagutelli, Xavier

Genetic Diversity of Collaborative Cross Mice Controls Viral Replication, Clinical Severity, and Brain Pathology Induced by Zika Virus Infection, Independently of Oas1b.

Manet, Caroline; Simon-Lorière, Etienne; Jouvion, Grégory; Hardy, David; Prot, Matthieu; Conquet, Laurine; Flamand, Marie; Panthier, Jean-Jacques; Sakuntabhai, Anavaj; Montagutelli, Xavier.

Afiliação

Manet C; Mouse Genetics Laboratory, Department of Genomes and Genetics, Institut Pasteur, Paris, France.
Simon-Lorière E; Evolutionary Genomics of RNA Viruses, Department of Virology, Institut Pasteur, Paris, France.
Jouvion G; Sorbonne Université, INSERM, Pathophysiology of Pediatric Genetic Diseases, AP-HP, Hôpital Armand-Trousseau, UF de Génétique Moléculaire, Paris, France.
Hardy D; Institut Pasteur, Experimental Neuropathology Unit, Department of Global Health, Paris, France.
Prot M; Institut Pasteur, Experimental Neuropathology Unit, Department of Global Health, Paris, France.
Conquet L; Evolutionary Genomics of RNA Viruses, Department of Virology, Institut Pasteur, Paris, France.
Flamand M; Mouse Genetics Laboratory, Department of Genomes and Genetics, Institut Pasteur, Paris, France.
Panthier JJ; Structural Virology Unit, Department of Virology, CNRS UMR 3569, Institut Pasteur, Paris, France.
Sakuntabhai A; Mouse Genetics Laboratory, Department of Genomes and Genetics, Institut Pasteur, Paris, France.
Montagutelli X; Functional Genetics of Infectious Diseases Unit, Department of Global Health, CNRS UMR 2000, Institut Pasteur, Paris, France.

J Virol ; 94(3)2020 01 17.

Article em En | MEDLINE | ID: mdl-31694939

Assuntos

Encéfalo/virologia; Camundongos de Cruzamento Colaborativo/genética; Variação Genética; Replicação Viral/fisiologia; Infecção por Zika virus/virologia; 2',5'-Oligoadenilato Sintetase; Animais; Encéfalo/patologia; Chlorocebus aethiops; Camundongos de Cruzamento Colaborativo/virologia; Modelos Animais de Doenças; Feminino; Humanos; Masculino; Camundongos; Camundongos Knockout; Receptor de Interferon alfa e beta; Células Vero; Carga Viral; Vírus do Nilo Ocidental; Zika virus/imunologia; Infecção por Zika virus/patologia

Palavras-chave

Collaborative Cross; Zika; Zika virus; flavivirus; genetic diversity; host genetics; mouse model

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Replicação Viral / Encéfalo / Infecção por Zika virus / Camundongos de Cruzamento Colaborativo Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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