The Pseudomonas aeruginosa HSP70-like protein DnaK induces IL-1ß expression via TLR4-dependent activation of the NF-&#954;B and JNK signaling pathways.

Lee, Jung-Hoon; Jeon, Jisu; Bai, Fang; Jin, Shouguang; Wu, Weihui; Ha, Un-Hwan

The Pseudomonas aeruginosa HSP70-like protein DnaK induces IL-1ß expression via TLR4-dependent activation of the NF-κB and JNK signaling pathways.

Lee, Jung-Hoon; Jeon, Jisu; Bai, Fang; Jin, Shouguang; Wu, Weihui; Ha, Un-Hwan.

Afiliação

Lee JH; Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Republic of Korea.
Jeon J; Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Republic of Korea.
Bai F; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, Nankai University, Tianjin 300071, China.
Jin S; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida 32610, USA.
Wu W; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, Nankai University, Tianjin 300071, China.
Ha UH; Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Republic of Korea. Electronic address: haunhwan@korea.ac.kr.

Comp Immunol Microbiol Infect Dis ; 67: 101373, 2019 Dec.

Article em En | MEDLINE | ID: mdl-31704499

Assuntos

Proteínas de Choque Térmico HSP70/metabolismo; Interleucina-1beta/metabolismo; Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo; NF-kappa B/metabolismo; Pseudomonas aeruginosa/imunologia; Receptor 4 Toll-Like/metabolismo; Células A549; Linhagem Celular; Humanos; Imunidade Inata/imunologia; Lipopolissacarídeos; Sistema de Sinalização das MAP Quinases/imunologia; Nigericina; Células THP-1

Palavras-chave

DnaK; IL-1ß; JNK; NF-κB; Pseudomonas aeruginosa; TLR4

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / NF-kappa B / Proteínas de Choque Térmico HSP70 / Proteínas Quinases JNK Ativadas por Mitógeno / Receptor 4 Toll-Like / Interleucina-1beta Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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