Synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives: Antimicrobial activity, DNA Gyrase inhibition and molecular docking.

Abd El-Aleam, Rehab H; George, Riham F; Hassan, Ghaneya S; Abdel-Rahman, Hamdy M

Abd El-Aleam, Rehab H; George, Riham F; Hassan, Ghaneya S; Abdel-Rahman, Hamdy M.

Afiliação

Abd El-Aleam RH; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Modern University for Technology and Information MTI, Cairo 11571, Egypt.
George RF; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt. Electronic address: riham.eskandar@pharma.cu.edu.eg.
Hassan GS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Badr University, Badr City, Cairo 11829, Egypt.
Abdel-Rahman HM; Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University, Beni Suef, Egypt.

Bioorg Chem ; 94: 103411, 2020 01.

Article em En | MEDLINE | ID: mdl-31711767

Assuntos

Antibacterianos/uso terapêutico; Simulação de Acoplamento Molecular/métodos; Pirimidinas/química; Pirimidinas/síntese química; Inibidores da Topoisomerase II/uso terapêutico; Antibacterianos/farmacologia; Humanos; Inibidores da Topoisomerase II/farmacologia

Palavras-chave

1,2,4-Triazolo[1,5-a]pyrimidine; Antibacterial; Antifungal; DNA Gyrase inhibitors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Inibidores da Topoisomerase II / Simulação de Acoplamento Molecular / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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