Extensive deletions and insertions in different MHC supratypes detected by pusled field gel electrophoresis.
J Exp Med
; 168(3): 933-40, 1988 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-3171479
ABSTRACT
The genomic organization of the human MHC was examined in multiple examples of six different supratypes using pulsed field electrophoresis (PFGE) after digestion of genomic DNA with infrequency cutting restriction endonucleases. Differences in restriction fragment length and band intensity were shown to be specific for each supratype. Mapping of the MHC revealed that each supratype contains previously undescribed deletions and insertions between HLA B and DQ regions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 6
/
Eletroforese
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Eletroforese em Gel de Ágar
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Complexo Principal de Histocompatibilidade
Limite:
Humans
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article