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The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis.
Oser, Matthew G; Sabet, Amin H; Gao, Wenhua; Chakraborty, Abhishek A; Schinzel, Anna C; Jennings, Rebecca B; Fonseca, Raquel; Bonal, Dennis M; Booker, Matthew A; Flaifel, Abdallah; Novak, Jesse S; Christensen, Camilla L; Zhang, Hua; Herbert, Zachary T; Tolstorukov, Michael Y; Buss, Elizabeth J; Wong, Kwok-Kin; Bronson, Roderick T; Nguyen, Quang-De; Signoretti, Sabina; Kaelin, William G.
Afiliação
  • Oser MG; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Sabet AH; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
  • Gao W; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Massachusetts 02115, USA.
  • Chakraborty AA; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Schinzel AC; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Jennings RB; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Massachusetts 02115, USA.
  • Fonseca R; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Bonal DM; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Massachusetts 02115, USA.
  • Booker MA; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Flaifel A; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Novak JS; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Massachusetts 02115, USA.
  • Christensen CL; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Zhang H; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Herbert ZT; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02210, USA.
  • Tolstorukov MY; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
  • Buss EJ; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Wong KK; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Massachusetts 02115, USA.
  • Bronson RT; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Nguyen QD; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Massachusetts 02115, USA.
  • Signoretti S; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
  • Kaelin WG; Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, New York 10016, USA.
Genes Dev ; 33(23-24): 1718-1738, 2019 12 01.
Article em En | MEDLINE | ID: mdl-31727771
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Diferenciação Celular / Receptores Notch / Células Neuroendócrinas / Carcinoma de Pequenas Células do Pulmão / Proteína 2 de Ligação ao Retinoblastoma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Diferenciação Celular / Receptores Notch / Células Neuroendócrinas / Carcinoma de Pequenas Células do Pulmão / Proteína 2 de Ligação ao Retinoblastoma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article