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A Single Synonymous Variant (c.354G>A [p.P118P]) in ADAMTS13 Confers Enhanced Specific Activity.
Hunt, Ryan; Hettiarachchi, Gaya; Katneni, Upendra; Hernandez, Nancy; Holcomb, David; Kames, Jacob; Alnifaidy, Redab; Lin, Brian; Hamasaki-Katagiri, Nobuko; Wesley, Aaron; Kafri, Tal; Morris, Christina; Bouché, Laura; Panico, Maria; Schiller, Tal; Ibla, Juan; Bar, Haim; Ismail, Amra; Morris, Howard; Komar, Anton; Kimchi-Sarfaty, Chava.
Afiliação
  • Hunt R; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation & Research, US FDA, Silver Spring, MD 20993, USA.
  • Hettiarachchi G; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation & Research, US FDA, Silver Spring, MD 20993, USA.
  • Katneni U; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation & Research, US FDA, Silver Spring, MD 20993, USA.
  • Hernandez N; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation & Research, US FDA, Silver Spring, MD 20993, USA.
  • Holcomb D; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation & Research, US FDA, Silver Spring, MD 20993, USA.
  • Kames J; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation & Research, US FDA, Silver Spring, MD 20993, USA.
  • Alnifaidy R; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation & Research, US FDA, Silver Spring, MD 20993, USA.
  • Lin B; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation & Research, US FDA, Silver Spring, MD 20993, USA.
  • Hamasaki-Katagiri N; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation & Research, US FDA, Silver Spring, MD 20993, USA.
  • Wesley A; Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Kafri T; Present Address: Department of Emergency Medicine, Banner University Medical Center, The University of Arizona, Tucson, AZ 85724, USA.
  • Morris C; Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Bouché L; BioPharmaSpec Ltd., St. Saviour JE2 7LA, UK.
  • Panico M; Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
  • Schiller T; Present Address: Antikor Biopharma Ltd., Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage SG1 2FX, UK.
  • Ibla J; BioPharmaSpec Ltd., St. Saviour JE2 7LA, UK.
  • Bar H; Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
  • Ismail A; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation & Research, US FDA, Silver Spring, MD 20993, USA.
  • Morris H; Departments of Cardiac Surgery and Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Komar A; Department of Statistics, University of Connecticut, Storrs, CT 06269, USA.
  • Kimchi-Sarfaty C; Center for Gene Regulation in Health and Disease, Department of Biological, Geological & Environmental Sciences, Cleveland State University, Cleveland, OH 44115, USA.
Int J Mol Sci ; 20(22)2019 Nov 15.
Article em En | MEDLINE | ID: mdl-31731663
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína ADAMTS13 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína ADAMTS13 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article