Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine- Based Radioligand for the Imaging of Phosphodiesterase 2A with Positron Emission Tomography.

Ritawidya, Rien; Wenzel, Barbara; Teodoro, Rodrigo; Toussaint, Magali; Kranz, Mathias; Deuther-Conrad, Winnie; Dukic-Stefanovic, Sladjana; Ludwig, Friedrich-Alexander; Scheunemann, Matthias; Brust, Peter

Ritawidya, Rien; Wenzel, Barbara; Teodoro, Rodrigo; Toussaint, Magali; Kranz, Mathias; Deuther-Conrad, Winnie; Dukic-Stefanovic, Sladjana; Ludwig, Friedrich-Alexander; Scheunemann, Matthias; Brust, Peter.

Afiliação

Ritawidya R; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Research Site Leipzig, Department of Neuroradiopharmaceuticals, 04318 Leipzig, Germany.
Wenzel B; Center for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency (BATAN), Puspiptek Area, Serpong, South Tangerang 15314, Indonesia.
Teodoro R; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Research Site Leipzig, Department of Neuroradiopharmaceuticals, 04318 Leipzig, Germany.
Toussaint M; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Research Site Leipzig, Department of Neuroradiopharmaceuticals, 04318 Leipzig, Germany.
Kranz M; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Research Site Leipzig, Department of Neuroradiopharmaceuticals, 04318 Leipzig, Germany.
Deuther-Conrad W; Tromsø PET Center, University Hospital of North Norway, 9009 Tromsø, Norway.
Dukic-Stefanovic S; Nuclear Medicine and Radiation Biology Research Group, The Arctic University of Norway, 9009 Tromsø, Norway.
Ludwig FA; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Research Site Leipzig, Department of Neuroradiopharmaceuticals, 04318 Leipzig, Germany.
Scheunemann M; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Research Site Leipzig, Department of Neuroradiopharmaceuticals, 04318 Leipzig, Germany.
Brust P; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Research Site Leipzig, Department of Neuroradiopharmaceuticals, 04318 Leipzig, Germany.

Molecules ; 24(22)2019 Nov 15.

Article em En | MEDLINE | ID: mdl-31731831

Assuntos

Encéfalo; Nucleotídeo Cíclico Fosfodiesterase do Tipo 2/metabolismo; Radioisótopos de Flúor; Neuroimagem; Tomografia por Emissão de Pósitrons; Compostos Radiofarmacêuticos; Animais; Encéfalo/diagnóstico por imagem; Encéfalo/enzimologia; Radioisótopos de Flúor/química; Radioisótopos de Flúor/farmacocinética; Radioisótopos de Flúor/farmacologia; Radioquímica; Compostos Radiofarmacêuticos/síntese química; Compostos Radiofarmacêuticos/química; Compostos Radiofarmacêuticos/farmacocinética; Compostos Radiofarmacêuticos/farmacologia; Suínos; Distribuição Tecidual

Palavras-chave

PDE2A radioligand; PET imaging; cyclic nucleotide phosphodiesterase; fluorine-18; in vitro autoradiography; nitro-precursor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Radioisótopos de Flúor / Compostos Radiofarmacêuticos / Tomografia por Emissão de Pósitrons / Nucleotídeo Cíclico Fosfodiesterase do Tipo 2 / Neuroimagem Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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