Design, synthesis and bio-evaluation of novel 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazoles as the tubulin polymerization inhibitors.

Huang, Liancheng; Liu, Meng; Man, Shuai; Ma, Deyi; Feng, Dongjie; Sun, Zhongqiao; Guan, Qi; Zuo, Daiying; Wu, Yingliang; Zhang, Weige; Bao, Kai

Huang, Liancheng; Liu, Meng; Man, Shuai; Ma, Deyi; Feng, Dongjie; Sun, Zhongqiao; Guan, Qi; Zuo, Daiying; Wu, Yingliang; Zhang, Weige; Bao, Kai.

Afiliação

Huang L; Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Liu M; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Man S; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Ma D; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Feng D; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Sun Z; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Guan Q; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Zuo D; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. Electronic address: zuodaiying@163.com.
Wu Y; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Zhang W; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. Electronic address: zhangweige2000@sina.com.
Bao K; Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. Electronic address: baokai@syphu.edu.cn.

Eur J Med Chem ; 186: 111846, 2020 Jan 15.

Article em En | MEDLINE | ID: mdl-31740055

Assuntos

Antineoplásicos/farmacologia; Desenho de Fármacos; Triazóis/farmacologia; Moduladores de Tubulina/farmacologia; Tubulina (Proteína)/metabolismo; Células A549; Antineoplásicos/síntese química; Antineoplásicos/química; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Células HeLa; Humanos; Modelos Moleculares; Estrutura Molecular; Polimerização/efeitos dos fármacos; Relação Estrutura-Atividade; Triazóis/síntese química; Triazóis/química; Moduladores de Tubulina/síntese química; Moduladores de Tubulina/química; Células Tumorais Cultivadas

Palavras-chave

Antiproliferative activities; Aqueous solubility; G2/M phase; Microtubule; Molecular modeling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazóis / Tubulina (Proteína) / Desenho de Fármacos / Moduladores de Tubulina / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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